Involvement of Two Types of TNF Receptor in TNF-α Induced Neutrophil Apoptosis

Involvement of FAN in TNF-induced apoptosis.

TNF-alpha is a pleiotropic cytokine activating several signaling pathways initiated at distinct intracellular domains of the TNF receptors. Although the C-terminal region is believed to be responsible for apoptosis induction, the functions of more membrane-proximal domains, including the domain that couples to neutral sphingomyelinase activation, are not yet fully elucidated. The roles of this ...

Effect of Exogenous Opioid Peptides on TNF-α-Induced Human Neutrophil Apoptosis in Vitro

Polymorphonuclear leukocyte (neutrophil) apoptosis is an important mechanism regulating the life span and some functions of neutrophils at inflamed sites. Opioid peptides are present in the peripheral circulation and their concentrations rapidly increase as a result of stress and inflammation. The effect of opioid peptides such as met-enkephalin (M-ENK) and β-endorphin (β-END) on tumor necrosis...

Cooperation of Both TNF Receptors in Inducing Apoptosis: Involvement of the TNF Receptor-Associated Factor Binding

Respiratory Burst TNF-Induced Activation of Neutrophil Role of the 75-kDa TNF Receptor in

Promotion of Neutrophil Apoptosis by TNF-a